{"product_id":"the-role-of-toll-like-receptor-4-in-infectious-and-non-infectious-inflammation","title":"The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation","description":"\u003cdiv\u003e\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003eTLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThis volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism\/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.\u003c\/p\u003e\n\u003cp\u003eThe book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer''s diseases,  and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4. \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":57492424753525,"sku":"9783030563219","price":88.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0612\/7193\/3106\/files\/9783030563219.jpg?v=1786529266","url":"https:\/\/backstory.london\/products\/the-role-of-toll-like-receptor-4-in-infectious-and-non-infectious-inflammation","provider":"Backstory","version":"1.0","type":"link"}